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M9480577.TXT
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1994-08-20
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Document 0577
DOCN M9480577
TI Cerebral glial tumors and human immunodeficiency virus-1 infection. More
than a coincidental association.
DT 9410
AU Moulignier A; Mikol J; Pialoux G; Eliaszewicz M; Thurel C; Thiebaut JB;
Hopital Tenon, Service de Neurologie, Paris, France.
SO Cancer. 1994 Jul 15;74(2):686-92. Unique Identifier : AIDSLINE
MED/94306330
AB BACKGROUND. The authors describe the clinical and morphologic patterns
in four patients with acquired immune deficiency syndrome (AIDS) who
developed intracranial glial tumors. METHODS. This retrospective study
reports 70 patients at various stages of human immunodeficiency virus-1
(HIV-1) infection who underwent stereotactic brain biopsy for an
intracerebral space-occupying lesion. RESULTS. Of these patients, four
had glial tumors: one astroblastoma, two astrocytomas, and one
glioblastoma. Glial tumors probably arise from a complex interplay of
factors; possibilities include the activation of a dominant oncogene or
viral inactivation of a tumor suppressor gene by a viral promoter (like
the tat protein), impairment of immune defenses (which facilitates the
growth of astrocytomas in acute lymphoblastic leukemia), production of
cellular growth factors, cytokines, possible infection of glial cells by
HIV, and the potentiation of a coinfectious agent. CONCLUSIONS. These
cases illustrate that glial tumors should be considered in the
differential diagnosis of brain masses in HIV-1 infection, especially
because specific treatment for these tumors is available. Moreover, the
occurrence of glial tumors in AIDS patients is not only an important
event from a clinical point of view, but may also have implications for
the pathogenesis of tumors in AIDS.
DE Acquired Immunodeficiency Syndrome/*COMPLICATIONS/GENETICS Adult Aged
Astrocytoma/ETIOLOGY Brain Neoplasms/*ETIOLOGY/GENETICS/PATHOLOGY
Female Glioblastoma/ETIOLOGY Glioma/*ETIOLOGY/GENETICS/PATHOLOGY
Human Male Middle Age Retrospective Studies Support, Non-U.S. Gov't
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).